OrganRegen-DAPT（C208255）
OrganRegen-DAPT（C208255）
货号：C208255
规格：20mg
品牌：OrganRegen
DAPT
货号：C208255
规格：20mg
品牌：OrganRegen
产品介绍
DESCRIPTION
Background
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2].
技术参数
Alias | GSI-IX | ||
M. W t | 432.46 | ||
Formula | C23H26F2N2O4 | ||
CAS No | |||
Storage | Powder | - 20°C | 2 years |
- 80°C | 3 years | ||
In solvent | - 80°C | 12 months | |
- 20°C | 3 months | ||
Solubility | DMSO | ≥ 100 mg/mL(283.71 mM) | |
Ethanol | 41 mg/mL(94.81 mM) | ||
H2O | < 0.1 mg/mL(insoluble) | ||
BIOLOGICAL ALTIVITY
In Vitro
[2].
[3].
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